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Cluster Allergy and Immunity - Nasal polyp, immunohistology (J. Esser-von Bieren)

Cluster Allergy and Immunity

Nasal polyp, immunohistology (J. Esser-von Bieren)

Cluster Allergy and Immunity - REM Ambrosia psilostachya (C. Weil, I. Weichenmeier, J. Buters)

Cluster Allergy and Immunity

REM Ambrosia psilostachya (C. Weil, I. Weichenmeier, J. Buters)

Cluster Allergy and Immunity - Gut cross section, histological staining (C. Ohnmacht)

Cluster Allergy and Immunity

Gut cross section, histological staining (C. Ohnmacht)

Research for a future without allergies

The Cluster Allergy and Immunity CAI integrates institutes with congruent research activities aiming at allergy prevention and remission. CAI partners include the Helmholtz Center Munich, the TUM, LMU, UNIKA-T Augsburg and the University Hospital Regensburg that practice research in a tightly integrated way and share a translational and interdisciplinary spirit that fosters creativity and innovation.​ Insights from the interplay of environment and men as well as cellular mechanisms are deliberately directed into preclinical models and - if proven effective - into clinical practice.

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News

EAACI Congress 2020 in London

The most important European congress for allergy and immunology will take place from 6 to 10 June 2020.

You can now submit your abstract and profit from the early bird registration fee until 6 February 2020.

link to the congress: here


 

Award for CAI researcher

Dr. Dennis Russkamp from the Research Group Molecular and Translational Allergology of PD Dr. Simon Blank (ZAUM) received the award "Advanced Immunotherapies for Allergic Diseases" from the German Society for Allergology and Clinical Immunology (DGAKI). PD Dr. Blank (photo) accepted the award on behalf of the DGAKI (Link to publication).

PD Dr. Alexander Zink of the Clinic for Dermatology and Allergology of the TUM received the "Specific Immunotherapy" award for his work on "Allergy and sensitization to Hymenoptera venoms in unreferred adults with high risk of sting exposure" (link to publication).  Dr. Zink was represented at the award ceremony by Prof. Brockow.

Furthermore, PhD student Johanna Krusche of the Allergy/ Immunology group (head: Prof. Schaub) was awarded the Young Investigators Prize for her work "TNFAIP3 is a key player in childhood asthma development and environment-mediated protection". (Link to publication)

The prizes are awarded annually and endowed with 5000 Euro. The award ceremony took place during the German Allergy Congress on 27 September 2018 in Hanover.


 

Internationally renowned Balzan Prize for lung researchers

Erika von Mutius and three colleagues (Klaus F. Rabe, Werner Seeger, Tobias Welte) from the German Center for Lung Research (Deutschen Zentrums für Lungenforschung) have been awarded with the „Balzan“ prize 2019. The international Balzan foundation appreciated the research on the “Pathophysiology of respiration: from basic research to the bedside”. The international jury was convinced by the researcher’s innovative concepts for therapy of lung diseases and education of young researchers in this field.

Balzan Foundation: LINK


 

New DFG funding for research on immune regulatory helminth proteins

ZAUM Arbeitsgruppenleiterin Julia Esser- von Bieren (Bild: HMGU)

Metabolites of the polyunsaturated fatty acid (PUFA) arachidonic acid (“eicosanoids”) play central and versatile roles in type 2 immune responses e.g. in allergy and asthma. However, current therapies fail to sufficiently target these important mediators. Julia Esser-von Bieren’s team at the ZAUM aims at identifying new molecules, which can regulate eicosanoid-driven airway inflammation. They now received renewed DFG funding to explore the mechanism of action of a newly identified immune- and eicosanoid-regulatory helminth protein. The team is studying potential anti-inflammatory effects of this protein in primary human immune cells and in experimental models of house dust mite allergy and helminth infection.

Publications:

Immune-regulation and -functions of eicosanoid lipid mediators. Esser-von Bieren J. Biol Chem. 2017 Oct

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions. Henkel FDR, Friedl A, Haid M, Thomas D, Bouchery T, Haimerl P, de Los Reyes Jiménez M, Alessandrini F, Schmidt-Weber CB, Harris NL, Adamski J, Esser-von Bieren J. Allergy. 2019 Jun

ZAUM Research group: link


 

Martha study- prevention of allergy and asthma

The MARTHA study initiated by Prof. Erika von Mutius is investigating the effect of differently processed milks on the development of asthma and allergies in children. This randomized trial wants to test the already well described protective "farm effect" which was partly explained by the consumption of unprocessed farm milk for an innovative prevention approach. The study team did already recruit over 580 study families.

for more information click here


Foto am Eröffnungstag mit den wichtigsten Akteuren des ZAUM, des LGL und Frau Staatsministerin Huml

Die bayerische Gesundheitsministerin Melanie Huml startete am 22. Mai 2019 das weltweit erste elektronische Polleninformationsnetzwerk (ePIN). Es dient der präzisen Messung und zeitnahen Veröffentlichung des aktuellen Pollenflugs in Bayern. Das Projekt basiert auf umfangreichen Vordatenaten des 'Zentrums für Allergie und Umwelt' der Technischen Universität und des Helmholtz Zentrums München (ZAUM) in Zusammenarbeit mit internationalen Experten und wurde im Auftrag des bayerischen Gesundheitsministeriums in Zusammenarbeit mit dem Umweltministerium durch das Bayerische Landesamt für Gesundheit und Lebensmittelsicherheit (LGL) aufgebaut und nun betrieben.

Weitere Informationen zu ePIN finden Sie hier


 

 

Prof. Dr.med. Zielinski (Bild: A. Heddergott / TUM)

A team working with Prof. Christina Zielinski at the Technical University of Munich (TUM) has demonstrated increased salt concentrations leads to the formation of Th2 cells in vitro, which are key cells in the development of allergic diseases such as atopic dermatitis. The team also detected elevated salt concentrations in the skin of patients with atopic dermatitis, which supports the growth of Staphylococcus aureus a bacterium associated with this disease.

Publikation: Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordstrom K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE. 2019. Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment. Sci Transl Med 11

Press release:

der TUM

Science daily


 

von li nach re: Dr. Matthias Reiger, Augsburg; Jana Mehlich, München; PD Dr. Patrick M. Brunner, MSc, Wien; Prof. Thomas Werfel DGAKI; Dr. Jose Oteros, München; PD Dr. Daniel Piotr Potaczek, Marburg
Bildquelle: DGAKI-2018

Wir gratulieren ganz herzlich:

Dr. Matthias Reiger, UNIKA-T Augsburg (links) und Jana Mehlich, Klinik und Poliklinik für Dermatologie und Allergologie der TU München (2. von links) für ihren Nachwuchsförderpreis der Siemens Healthcare Diagnostics GmbH, Eschborn und Dr. Jose Oteros aus dem ZAUM - Zentrum für Allergie und Umwelt (2. von rechts)  zum Förderpreis „Spezifische Immuntherapie“ der Allergopharma GmbH & Co. KG, Reinbek.

Sie wurden für Ihre Leistungen im Rahmen der Jahrestagung 2018 der deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI) in Dresden ausgezeichnet.

Diese Auszeichnungen stellen eine Würdigung der exzellenten Forschung im Bereich Allergie und Immunität im Großraum München dar!


 

von links: Dr. Alexander Zink (Oberarzt/ Dermatologie), Teilnehmerin mit dem jüngsten Teilnehmer, PD Dr. Kuschel (Leiterin der Geburtshilfe und Perinatalmedizin) und Prof. Biedermann (Klinikdirektor der Dermatologie).

Die "Munich Atopy Prediction Study" (MAPS) untersucht Risikofaktoren für Neurodermitis bei Kindern. Hierfür rekrutiert die Klinik für Dermatologie und Allergologie insgesamt 300 schwangere Frauen, deren Kinder im Klinikum rechts der Isar zur Welt kommen und im Großraum München wohnen werden. Teilnehmende Kinder werden eng betreut und erhalten im Fall einer Erkrankung an Neurodermitis die bestmögliche Therapie durch die Ärzte der Dermatologischen Universitätsklinik am Klinikum rechts der Isar.

Neurodermitis ist eine Volkskrankheit, von der zehn bis 15 Prozent der Kinder und zwei bis drei Prozent der Erwachsenen betroffen sind – mit jährlich steigender Tendenz. Die medizinische Forschung arbeitet daran, ein besseres Verständnis für das Erkrankungsbild zu gewinnen, um bessere Therapien entwickeln zu können. Wir fragen uns, welche Faktoren das Entstehen der Krankheit beeinflussen? Welche Rolle spielen Hautbakterien, die Darmflora, die Umwelt, unsere Gene? In der MAPS-Studie suchen wir ganz gezielt nach diesen Risikofaktoren für die Entwicklung allergologischer und dermatologischer Erkrankungen.


 

Atopic dermatitis: staphylococci-dominated microbiome influence skin barrier function

Staphylococcus aureus is the dominat skin associated bacterium in atopic dermatis. A recently published Paper of CAI Researchers in cooperation with researchers from Zurich could show that this microbiome dysbiosis influence also the skin barrier function.

 

Publication

Relations between epidermal barrier dysregulation and staphylococci-dominated microbiome dysbiosis in atopic dermatitis.

Altunbulakli C, Reiger M, Neumann AU, Garzorz-Stark N, Fleming M, Huelpuesch C, Castro-Giner F, Eyerich K, Akdis CA, Traidl-Hoffmann C.

J Allergy Clin Immunol. 2018 Jul

Press release TUM, August 10, 2018 (in german language)


 

CAI Publications

 

Next generation pollen monitoring and dissemination.

Buters J, Schmidt-Weber C, Oteros J.

Allergy. 2018 Aug


Characterization of the honeybee venom proteins C1q-like protein and PVF1 and their allergenic potential.

Russkamp D, Van Vaerenbergh M, Etzold S, Eberlein B, Darsow U, Schiener M, De Smet L, Absmaier M, Biedermann T, Spillner E, Ollert M, Jakob T, Schmidt-Weber CB, de Graaf DC, Blank S.

Toxicon. 2018 Aug


Protective effects of breastfeeding on respiratory symptoms in infants with 17q21 asthma risk variants.

Gorlanova O, Illi S, Toncheva AA, Usemann J, Latzin P, Kabesch M, Dalphin JC, Lauener R, Pekkanen JR, Von Mutius E, Riedler J, Kuehni CE, Röösli M, Frey U; BILD and PASTURE study groups.

Allergy. 2018 Jul


Relations between epidermal barrier dysregulation and staphylococci-dominated microbiome dysbiosis in atopic dermatitis.

 

Altunbulakli C, Reiger M, Neumann AU, Garzorz-Stark N, Fleming M, Huelpuesch C, Castro-Giner F, Eyerich K, Akdis CA, Traidl-Hoffmann C.

J Allergy Clin Immunol. 2018 Jul



Artemisia pollen is the main vector for airborne endotoxin.

Oteros J, Bartusel E, Alessandrini F, Núñez A, Moreno DA, Behrendt H, Schmidt-Weber C, Traidl-Hoffmann C, Buters J.

J Allergy Clin Immunol. 2018 Jul


Context matters: TH2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.

Aglas L, Gilles S, Bauer R, Huber S, Araujo GR, Mueller G, Scheiblhofer S, Amisi M, Dang HH, Briza P, Bohle B, Horejs-Hoeck J, Traidl-Hoffmann C, Ferreira F.

J Allergy Clin Immunol. 2018 May


Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.

Dehmel S, Nathan P, Bartel S, El-Merhie N, Scherb H, Milger K, John-Schuster G, Yildirim AO, Hylkema M, Irmler M, Beckers J, Schaub B, Eickelberg O, Krauss-Etschmann S.

Sci Rep. 2018 May


Activin-A Is a Pro-Inflammatory Regulator in Type-2-Driven Upper Airway Disease.

Chaker AM, Zissler UM, Poulos N, Wagenmann M, Bas M, Gürth F, Xanthou G, Schmidt-Weber C

Int Arch Allergy Immunol. 2018


Cutaneous Barriers and Skin Immunity: Differentiating A Connected Network.


Eyerich S, Eyerich K, Traidl-Hoffmann C, Biedermann T.

2018, Trends Immunol. - Review.


Type I immune response induces keratinocyte necroptosis and is associated with interface dermatitis.


Lauffer F, Jargosch M, Krause L, Garzorz-Stark N, Franz R, Roenneberg S, Böhner A, Mueller NS, Theis FJ, Schmidt-Weber CB, Biedermann T, Eyerich S, Eyerich K.

2018, J Invest Dermatol.


The use of pharmacogenomics, epigenomics, and transcriptomics to improve childhood asthma management: Where do we stand?


Farzan N, Vijverberg SJ, Kabesch M, Sterk PJ, Maitland-van der Zee AH.

2018, Pediatr Pulmonol.


Exposure to non-microbial N -Glycolylneuraminic acid protects farmers’ children against airway inflammation and colitis.

Remo Frei, Ruth Ferstl, Caroline Roduit, Mario Ziegler Dipl-Ing, Elisa Schiavi, Weronika Barcik, Noelia Rodriguez-Perez, Oliver F. Wirz, Marcin Wawrzyniak, Benoit Pugin, Dirk Nehrbass, Marek Jutel, Sylwia Smolinska, Patrycja Konieczna, Christian Bieli, Susanne Loeliger, Marco Waser, Göran Pershagen, Josef Riedler, Martin Depner, Bianca Schaub, Jon Genuneit, Harald Renz, Juha Pekkanen, Anne M. Karvonen, Jean-Charles Dalphin, Marianne van Hage, Gert Doekes, Mübeccel Akdis, Charlotte Braun-Fahrländer, Cezmi A. Akdis, Erika von Mutius, Liam O’Mahony, Roger P. Lauener.

2017, J Allergy Clin Immun.

Press release


 

Cabinet approves the electronic pollen information network "ePIN"

Prof. Dr. Jeroen Buters, ZAUM 

ePIN-network map     press release

 

 

 

We use cookies to improve your experience on our Website. We need cookies to continually improve our services, enable certain features, and when we embed third-party services or content, such as the Vimeo video player or Twitter feeds. In such cases, information may also be transferred to third parties. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.